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Methotrexate 2.5 mg Tablet

Methotrexate 2.5 mg Tablet

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Methotrexate 2.5 mg Tablet

Indications :

 

  • Trophoblastic neoplasms (chorioadenoma destruens, choriocarcinoma, and hydatidiform mole).

  • Acute lymphocytic leukemia (ALL)

  • Meningeal leukemia or meningeal leukemia

  • Breast cancer

  • Head and neck cancer

  • Cutaneous T-cell lymphoma (mycosis fungoides)

  • Lung cancer

  • Non-Hodgkin's lymphoma (NHL)

  • Burkitt's Lymphoma

  • Osteogenic sarcoma


 

Dosage :

 

Trophoblastic Neoplasms Adults : 15-30mg peroral (PO)/ intramuscular (IM) once daily, given for 5 days.

Acute Lymphocyic Leukemia Adults & children
: 3.3mg/m2 IV daily for 4-6 weeks or followed by maintenance therapy with 20-30mg/m2/PO/IM given twice weekly.

Breast Cancer Adults & Children
: 40-60mg/m2 IV given on day 1 of every 21-28 days along with cyclophosphamide & fluorouracil.

Head & Neck Cancer Adults & Children
: 40mg/m2 IV on days 1 & 15 of every 21 days alone or with bleomycin & cisplatin.

Cutaneous T-cell Lymphoma Adults
: 50mg IM once weekly or 25mg twice weekly.

Lung Cancer
: Methotrexate 20mg/m2 IV as a single dose along with cisplatin, doxorubicin & cyclophosphamide repeated every 28 days.

Dosage Adjustment :

Renal Impairment : Required.

Hepatic Impairment : Required.